The Spanish Chromosome 16 Consortium is integrated in the Human Proteome Project (HPP) that aims to develop an entire map of the proteins encoded by the human genome following a chromosome-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP).
The project is conceived on a multi-centric configuration, assuming the standards and integration procedures already available in ProteoRed-ISCIII, which is encompassed with HUPO initiatives. The Spanish consortium in composed of 21 research units organized in five working groups: Protein/Antibody micro Arrays and Peptide Standard, S/MRM team, Protein Sequencing, Bioinformatics and Clinical healthcare and Biobanking.
The products of the 840 protein coding genes in chromosome 16 are being analysed in Ramos, Jurkat cells, MCF-7 and CCD18 cells as it is theoretically expected that most chromosome 16 protein coding genes are expressed in at least one of these cell lines.
The B/D section has been structured around five main topics: cancer, obesity, and cardiovascular, infectious and rheumatic diseases. Furthermore, a bio-banking initiative has been designed to optimize methods for sample collection, management and storage under normalized conditions, and to define QC standards.