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SpHPP Chr16 Consortium

The Spanish participation in the Human Proteome Project

The Spanish Chromosome 16 Consortium is integrated in the Human Proteome Project (HPP) that aims to develop an entire map of the proteins encoded by the human genome following a chromosome-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP).

The project is conceived on a multi-centric configuration, assuming the standards and integration procedures already available in ProteoRed-ISCIII, which is encompassed with HUPO initiatives. The Spanish consortium in composed of 21 research units organized in five working groups: Protein/Antibody micro Arrays and Peptide Standard, S/MRM team, Protein Sequencing, Bioinformatics and Clinical healthcare and Biobanking.

The products of the 840 protein coding genes in chromosome 16 are being analysed in Ramos, Jurkat cells, MCF-7 and CCD18 cells as it is theoretically expected that most chromosome 16 protein coding genes are expressed in at least one of these cell lines.
The B/D section has been structured around five main topics: cancer, obesity, and cardiovascular, infectious and rheumatic diseases. Furthermore, a bio-banking initiative has been designed to optimize methods for sample collection, management and storage under normalized conditions, and to define QC standards.

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